Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the Iranian population.

ABSTRACT:

Background

Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Tumor necrosis factor-α (TNF-α) microsatellite as a proinflammatory cytokine is believed to play an important role in the etiology of this disease.

Objectives

The aim of this study was to investigate the association of TNF-α microsatellite sequence variation in patients with MS and its risk factor in the southern Iranian population.

Patients and methods

This polymorphism was investigated in an Iranian population of 163 native southern people [81 patients with MS according to the poser criteria and 82 healthy controls (HC) with the same age, sex, social, ethnical and geographical features (Hormozgan and Fars provinces)]. All the controls were nonimmunological, neurological patients.

SUBMITTER: Rahmanian M 

PROVIDER: S-EPMC4341370 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature