X-linked adrenoleukodystrophy: correlation between Loes score and diffusion tensor imaging parameters.

ABSTRACT:

Objective

The present study was aimed at evaluating the correlation between diffusion tensor imaging parameters and Loes score as well as whether those parameters could indicate early structural alterations.

Materials and methods

Diffusion tensor imaging measurements were obtained in 30 studies of 14 patients with X-linked adrenoleukodystrophy and were correlated with Loes scores. A control group including 28 male patients was created to establish agematched diffusion tensor imaging measurements. Inter- and intraobserver statistical analyses were undertaken.

Results

Diffusion tensor imaging measurements presented strong Pearson correlation coefficients (r) of -0.86, 0.89, 0.89 and 0.84 for fractional anisotropy and mean, radial and axial diffusivities (p < 0.01). Anal

SUBMITTER: Ono SE 

PROVIDER: S-EPMC4341377 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature