Aberrant Functional Connectivity in the Default Mode and Central Executive Networks in Subjects with Schizophrenia - A Whole-Brain Resting-State ICA Study.

ABSTRACT: Neurophysiological changes of schizophrenia are currently linked to disturbances in connectivity between functional brain networks. Functional magnetic resonance imaging studies on schizophrenia have focused on a few selected networks. Also previously, it has not been possible to discern whether the functional alterations in schizophrenia originate from spatial shifting or amplitude alterations of functional connectivity. In this study, we aim to discern the differences in schizophrenia patients with respect to spatial shifting vs. signal amplitude changes in functional connectivity in the whole-brain connectome. We used high model order-independent component analysis to study some 40 resting-state networks (RSN) covering the whole cortex. Group differences were analyzed with dual regressi

SUBMITTER: Littow H 

PROVIDER: S-EPMC4341512 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature