Improvement in liver histology is associated with reduction in dyslipidemia in children with nonalcoholic fatty liver disease.

ABSTRACT:

Objectives

Nonalcoholic fatty liver disease (NAFLD), the most common cause of liver disease among US children, may be associated with cardiovascular disease (CVD) risk. The present study sought to determine the prevalence of dyslipidemia in children with NAFLD and assess dyslipidemia by liver histology and histologic changes.

Methods

Individuals in the Treatment of NAFLD in Children (TONIC) trial were included (N = 173). In the TONIC trial, children with NAFLD were randomized to vitamin E, metformin, or placebo for 96 weeks. Nonalcoholic steatohepatitis (NASH) improved in 56 children. Change in lipid levels from baseline and 96 weeks was compared between patients with and without histologic improvement and with and without NASH.

Results

Dyslipidemia was frequent, with

SUBMITTER: Corey KE 

PROVIDER: S-EPMC4341955 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature