A new clinically based staging system for perihilar cholangiocarcinoma.

ABSTRACT:

Objectives

Current staging systems for perihilar cholangiocarcinoma (pCCA) are inadequate, as they are based on surgical pathology and therefore not relevant to unresectable patients. Clinical trials for potential targeted therapies for pCCA are hampered by the lack of an accurate, nonoperative staging system for predicting survival. We aimed at developing a clinical staging system for pCCA, which would be of prognostic relevance for all pCCA patients and help stratify patients for clinical trials.

Methods

Clinical information at the time of pCCA diagnosis of 413 patients seen at Mayo Clinic, Rochester, MN between 2002 and 2010 was retrospectively analyzed. A survival predictive model was developed using Cox proportional hazards analysis. The performance of the staging syste

SUBMITTER: Chaiteerakij R 

PROVIDER: S-EPMC4341961 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature