Second-generation PLINK: rising to the challenge of larger and richer datasets.

ABSTRACT:

Background

PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (GWAS) and research in population genetics. However, the steady accumulation of data from imputation and whole-genome sequencing studies has exposed a strong need for faster and scalable implementations of key functions, such as logistic regression, linkage disequilibrium estimation, and genomic distance evaluation. In addition, GWAS and population-genetic data now frequently contain genotype likelihoods, phase information, and/or multiallelic variants, none of which can be represented by PLINK 1's primary data format.

Findings

To address these issues, we are developing a second-generation codebase for PLINK. The first major release from this codebase, PLINK 1.9, introduces exte

SUBMITTER: Chang CC 

PROVIDER: S-EPMC4342193 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature