Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection.

ABSTRACT:

Background

During intra-erythrocytic development, late asexually replicating Plasmodium falciparum parasites sequester from peripheral circulation. This facilitates chronic infection and is linked to severe disease and organ-specific pathology including cerebral and placental malaria. Immature gametocytes - sexual stage precursor cells - likewise disappear from circulation. Recent work has demonstrated that these sexual stage parasites are located in the hematopoietic system of the bone marrow before mature gametocytes are released into the bloodstream to facilitate mosquito transmission. However, as sequestration occurs only in vivo and not during in vitro culture, the mechanisms by which it is regulated and enacted (particularly by the gametocyte stage) remain poorly understood.<

SUBMITTER: Pelle KG 

PROVIDER: S-EPMC4342211 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature