Characterization of the interaction between Rfa1 and Rad24 in Saccharomyces cerevisiae.

ABSTRACT: Maintaining the integrity of the genome requires the high fidelity duplication of the genome and the ability of the cell to recognize and repair DNA lesions. The heterotrimeric single stranded DNA (ssDNA) binding complex Replication Protein A (RPA) is central to multiple DNA processes, which are coordinated by RPA through its ssDNA binding function and through multiple protein-protein interactions. Many RPA interacting proteins have been reported through large genetic and physical screens; however, the number of interactions that have been further characterized is limited. To gain a better understanding of how RPA functions in DNA replication, repair, and cell cycle regulation and to identify other potential functions of RPA, a yeast two hybrid screen was performed using the yeast 70 kDa s

SUBMITTER: Piya G 

PROVIDER: S-EPMC4342240 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature