The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications.

ABSTRACT: Cushing's syndrome is associated with increased mortality, mainly due to cardiovascular complications, which are sustained by the common development of systemic arterial hypertension and metabolic syndrome, which partially persist after the disease remission. Cardiovascular diseases and hypertension associated with endogenous hypercortisolism reveal underexplored peculiarities. The use of exogenous corticosteroids also impacts on hypertension and cardiovascular system, especially after prolonged treatment. The mechanisms involved in the development of hypertension differ, whether glucocorticoid excess is acute or chronic, and the source endogenous or exogenous, introducing inconsistencies among published studies. The pleiotropic effects of glucocorticoids and the overlap of the several reg

SUBMITTER: Isidori AM 

PROVIDER: S-EPMC4342316 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature