Comparative risk of ischemic stroke among users of clopidogrel together with individual proton pump inhibitors.

ABSTRACT:

Background and purpose

There is controversy and little information about whether individual proton pump inhibitors (PPIs) differentially alter the effectiveness of clopidogrel in reducing ischemic stroke risk. We, therefore, aimed to elucidate the risk of ischemic stroke among concomitant users of clopidogrel and individual PPIs.

Methods

We conducted a propensity score-adjusted cohort study of adult new users of clopidogrel, using 1999 to 2009 Medicaid claims from 5 large states. Exposures were defined by prescriptions for esomeprazole, lansoprazole, omeprazole, rabeprazole, and pantoprazole-with pantoprazole serving as the referent. The end point was hospitalization for acute ischemic stroke, defined by International Classification of Diseases Ninth Revision Clinical Modifi

SUBMITTER: Leonard CE 

PROVIDER: S-EPMC4342326 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature