Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women.

ABSTRACT:

Objective

Family studies and twin studies demonstrate that lower urinary tract symptoms and pelvic organ prolapse are heritable. This review aimed to identify genetic polymorphisms tested for an association with lower urinary tract symptoms or prolapse, and to assess the strength, consistency, and risk of bias among reported associations.

Study design

PubMed and HuGE Navigator were searched up to May 1, 2014, using a combination of genetic and phenotype key words, including "nocturia," "incontinence," "overactive bladder," "prolapse," and "enuresis." Major genetics, urology, and gynecology conference abstracts were searched from 2005 through 2013. We screened 889 abstracts, and retrieved 78 full texts. In all, 27 published and 7 unpublished studies provided data on polymorph

SUBMITTER: Cartwright R 

PROVIDER: S-EPMC4342521 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature