Self-similarity of human protein interaction networks: a novel strategy of distinguishing proteins.

ABSTRACT: The successful determination of reliable protein interaction networks (PINs) in several species in the post-genomic era has hitherto facilitated the quest to understanding systems and structural properties of such networks. It is envisaged that a clearer understanding of their intrinsic topological properties would elucidate evolutionary and biological topography of organisms. This, in turn, may inform the understanding of diseases' aetiology. By analysing sub-networks that are induced in various layers identified by zones defined as distance from central proteins, we show that zones of human PINs display self-similarity patterns. What is observed at a global level is repeated at lower levels of inducement. Furthermore, it is observed that these levels of strength point to refinement and s

SUBMITTER: Fadhal E 

PROVIDER: S-EPMC4342563 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature