Leveraging biospecimen resources for discovery or validation of markers for early cancer detection.

ABSTRACT: Validation of early detection cancer biomarkers has proven to be disappointing when initial promising claims have often not been reproducible in diagnostic samples or did not extend to prediagnostic samples. The previously reported lack of rigorous internal validity (systematic differences between compared groups) and external validity (lack of generalizability beyond compared groups) may be effectively addressed by utilizing blood specimens and data collected within well-conducted cohort studies. Cohort studies with prediagnostic specimens (eg, blood specimens collected prior to development of clinical symptoms) and clinical data have recently been used to assess the validity of some early detection biomarkers. With this background, the Division of Cancer Control and Population Sciences (

SUBMITTER: Schully SD 

PROVIDER: S-EPMC4342676 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature