Extrapolating histone marks across developmental stages, tissues, and species: an enhancer prediction case study.

ABSTRACT:

Background

Dynamic activation and inactivation of gene regulatory DNA produce the expression changes that drive the differentiation of cellular lineages. Identifying regulatory regions active during developmental transitions is necessary to understand how the genome specifies complex developmental programs and how these processes are disrupted in disease. Gene regulatory dynamics are mediated by many factors, including the binding of transcription factors (TFs) and the methylation and acetylation of DNA and histones. Genome-wide maps of TF binding and DNA and histone modifications have been generated for many cellular contexts; however, given the diversity and complexity of animal development, these data cover only a small fraction of the cellular and developmental contexts of inte

SUBMITTER: Capra JA 

PROVIDER: S-EPMC4342796 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature