Identification of radiation-induced aberrant hypomethylation in colon cancer.

ABSTRACT:

Background

Exposure to ionizing radiation (IR) results in the simultaneous activation or downregulation of multiple signaling pathways that play critical roles in cell type-specific control of survival or death. IR is a well-known genotoxic agent and human carcinogen that induces cellular damage through direct and indirect mechanisms. However, its impact on epigenetic mechanisms has not been elucidated, and more specifically, little information is available regarding genome-wide DNA methylation changes in cancer cells after IR exposure. Recently, genome-wide DNA methylation profiling technology using the Illumina HumanMethylation450K platform has emerged that allows us to query >450,000 loci within the genome. This improved technology is capable of identifying genome-wide DNA methy

SUBMITTER: Bae JH 

PROVIDER: S-EPMC4342812 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature