CHRNA4 rs1044396 is associated with smoking cessation in varenicline therapy.

ABSTRACT:

Background

The large individual variability in response to drugs for smoking cessation suggests that specific treatments can be more effective in particular subgroups of smokers. In the context of personalized medicine, the main aim of the present study was to evaluate whether the CHRNA4 and CHRNB2 polymorphisms are associated with response to smoking cessation therapies in patients from a smoker assistance program.

Methods

This cohort study enrolled 483 smoking patients who received behavioral counseling and drug treatment (varenicline, bupropion, and/or nicotine replacement therapy). Smoking cessation success was considered for patients who completed 6 months of continuous abstinence. Fagerström test for nicotine dependence (FTND) and Issa situational smoking scores were a

SUBMITTER: Rocha Santos J 

PROVIDER: S-EPMC4343187 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature