G6PD gene variants and its association with malaria in a Sri Lankan population.

ABSTRACT:

Background

Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that plays an important role in many cellular functions. Deficiency of this enzyme results from point mutations in the coding region of the G6PD gene. G6PD-deficiency is important in malaria, as certain anti-malarial drugs could induce haemolysis in such patients and mutations in this gene may influence the susceptibility or resistance to the disease. Detailed information on genetic variations in the G6PD gene for Sri Lankan populations is yet to be revealed. This study describes a set of G6PD mutations present in a Sri Lankan population and their association with uncomplicated malaria.

Methods

DNA was extracted from 1,051 individuals. Sixty-eight SNPs in the region of the G6PD gene were genotyped. A database c

SUBMITTER: Dewasurendra RL 

PROVIDER: S-EPMC4343272 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature