MeSH ORA framework: R/Bioconductor packages to support MeSH over-representation analysis.

ABSTRACT:

Background

In genome-wide studies, over-representation analysis (ORA) against a set of genes is an essential step for biological interpretation. Many gene annotation resources and software platforms for ORA have been proposed. Recently, Medical Subject Headings (MeSH) terms, which are annotations of PubMed documents, have been used for ORA. MeSH enables the extraction of broader meaning from the gene lists and is expected to become an exhaustive annotation resource for ORA. However, the existing MeSH ORA software platforms are still not sufficient for several reasons.

Results

In this work, we developed an original MeSH ORA framework composed of six types of R packages, including MeSH.db, MeSH.AOR.db, MeSH.PCR.db, the org.MeSH.XXX.db-type packages, MeSHDbi, and meshr.

Conc

SUBMITTER: Tsuyuzaki K 

PROVIDER: S-EPMC4343279 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature