Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine.

ABSTRACT:

Objectives

The purpose of this study was to test the hypothesis that the late Na current blocker ranolazine suppresses re-entrant and multifocal ventricular fibrillation (VF).

Background

VF can be caused by either re-entrant or focal mechanism.

Methods

Simultaneous voltage and intracellular Ca(+)² optical mapping of the left ventricular epicardial surface along with microelectrode recordings was performed in 24 isolated-perfused aged rat hearts. Re-entrant VF was induced by rapid pacing and multifocal VF by exposure to oxidative stress with 0.1 mM hydrogen peroxide (H₂O₂).

Results

Rapid pacing induced sustained VF in 7 of 8 aged rat hearts, characterized by 2 to 4 broad propagating wavefronts. Ranolazine significantly (p < 0.05) reduced the maximum slope of act

SUBMITTER: Morita N 

PROVIDER: S-EPMC4344130 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature