Increased lung and bladder cancer incidence in adults after in utero and early-life arsenic exposure.

ABSTRACT:

Background

From 1958 to 1970, >100,000 people in northern Chile were exposed to a well-documented, distinct period of high drinking water arsenic concentrations. We previously reported ecological evidence suggesting that early-life exposure in this population resulted in increased mortality in adults from several outcomes, including lung and bladder cancer.

Methods

We have now completed the first study ever assessing incident cancer cases after early-life arsenic exposure, and the first study on this topic with individual participant exposure and confounding factor data. Subjects included 221 lung and 160 bladder cancer cases diagnosed in northern Chile from 2007 to 2010, and 508 age and gender-matched controls.

Results

ORs adjusted for age, sex, and smoking in those

SUBMITTER: Steinmaus C 

PROVIDER: S-EPMC4344186 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature