Predicting the outcome of Sjogren's syndrome-associated non-hodgkin's lymphoma patients.

ABSTRACT:

Background

Non-Hodgkin's lymphoma (NHL) development in Sjögren's syndrome (SS) remains a potentially lethal complication and efforts should focus on the identification of predictors that could aid in appropriate therapeutic decisions.

Methods

In order to identify potential prognostic factors for outcome in SS-associated NHL, we retrospectively analyzed a cohort of 77 patients, diagnosed with NHL according to WHO classification criteria and meeting the American-European Consensus Classification (AECC) criteria for SS and examined the effect of SS-activity (defined as the EULAR SS disease activity index-ESSDAI) in the prognosis of SS-related NHLs, as defined in terms of overall and event-free survivals (OS and EFS). An event was defined as lymphoma relapse, treatment failure,

SUBMITTER: Papageorgiou A 

PROVIDER: S-EPMC4344229 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature