A multimeric MR-optical contrast agent for multimodal imaging.

ABSTRACT: We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.

SUBMITTER: Harrison VS 

PROVIDER: S-EPMC4344311 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature