Cofilin1 controls transcolumnar plasticity in dendritic spines in adult barrel cortex.

ABSTRACT: During sensory deprivation, the barrel cortex undergoes expansion of a functional column representing spared inputs (spared column), into the neighboring deprived columns (representing deprived inputs) which are in turn shrunk. As a result, the neurons in a deprived column simultaneously increase and decrease their responses to spared and deprived inputs, respectively. Previous studies revealed that dendritic spines are remodeled during this barrel map plasticity. Because cofilin1, a predominant regulator of actin filament turnover, governs both the expansion and shrinkage of the dendritic spine structure in vitro, it hypothetically regulates both responses in barrel map plasticity. However, this hypothesis remains untested. Using lentiviral vectors, we knocked down cofilin1 locally within

SUBMITTER: Tsubota T 

PROVIDER: S-EPMC4344332 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature