Raltegravir non-inferior to nucleoside based regimens in second-line therapy with lopinavir/ritonavir over 96 weeks: a randomised open label study for the treatment of HIV-1 infection.

ABSTRACT:

Objective

To determine the durability over 96 weeks of safety and efficacy of lopinavir/ritonavir (LPV/r) and raltegravir (RAL) which was demonstrated to have non-inferior efficacy relative to a regimen of LPV/r with nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTIs) (Control) in primary analysis at 48 weeks.

Design

Open label, centrally randomised trial.

Setting

Recruitment was from 37 primary and secondary care sites from Africa, Asia, Australia, Europe and Latin America.

Subjects

541 HIV-1 infected adults virologically failing first-line non-NRTI + 2N(t)RTI, with no previous exposure to protease inhibitors or integrase strand transfer inhibitors were analysed, 425 completed 96 weeks follow up on randomised therapy.

Intervention

Randomis

SUBMITTER: Amin J 

PROVIDER: S-EPMC4344344 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature