Subcutaneous adipose cell size and distribution: relationship to insulin resistance and body fat.

ABSTRACT:

Objective

Metabolic heterogeneity among obese individuals may be attributable to differences in adipose cell size. We sought to clarify this by quantifying adipose cell size distribution, body fat, and insulin-mediated glucose uptake in overweight to moderately-obese individuals.

Methods

A total of 148 healthy nondiabetic subjects with BMI 25-38 kg/m2 underwent subcutaneous adipose tissue biopsies and quantification of insulin-mediated glucose uptake with steady-state plasma glucose (SSPG) concentrations during the modified insulin suppression test. Cell size distributions were obtained with Beckman Coulter Multisizer. Primary endpoints included % small adipose cells and diameter of large adipose cells. Cell-size and metabolic parameters were compared by regression for the w

SUBMITTER: McLaughlin T 

PROVIDER: S-EPMC4344365 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature