Pilot dietary intervention with heat-stabilized rice bran modulates stool microbiota and metabolites in healthy adults.

ABSTRACT: Heat-stabilized rice bran (SRB) has been shown to regulate blood lipids and glucose, modulate gut mucosal immunity and inhibit colorectal cancer in animal and human studies. However, SRB's effects on gut microbial composition and metabolism and the resulting implications for health remain largely unknown. A pilot, randomized-controlled trial was developed to investigate the effects of eating 30 g/day SRB on the stool microbiome and metabolome. Seven healthy participants consumed a study meal and snack daily for 28 days. The microbiome and metabolome were characterized using 454 pyrosequencing and gas chromatography-mass spectrometry (GC-MS) at baseline, two and four weeks post-intervention. Increases in eight operational taxonomic units (OTUs), including three from Bifidobacterium and Rumi

SUBMITTER: Sheflin AM 

PROVIDER: S-EPMC4344588 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature