Identification of a novel microRNA signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis.

ABSTRACT:

Background

The clinical significance of microRNAs (miRNAs) in intrahepatic cholangiocarcinoma (ICC) is unclear. The objective of this study is to examine the miRNA expression profiles and identify a miRNA signature for the prognosis of ICC.

Methods

Using a custom microarray containing 1,094 probes, the miRNA expression profiles of 63 human ICCs and nine normal intrahepatic bile ducts (NIBD) were assessed. The miRNA signatures were established and their clinical significances in ICC were analyzed. The expression levels of some miRNAs were verified by quantitative real-time RT-PCR (qRT-PCR).

Results

Expression profile analysis showed 158 differentially expressed miRNAs between ICC and NIBD, with 77 up-regulated and 81 down-regulated miRNAs. From the 158 differentially e

SUBMITTER: Zhang MY 

PROVIDER: S-EPMC4344737 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature