MicroRNA-dependent temporal gene expression in the ureteric bud epithelium during mammalian kidney development.

ABSTRACT:

Background

Our previous study on mouse mutants with the ureteric bud (UB) epithelium-specific Dicer deletion (Dicer UB mutants) demonstrated the significance of UB epithelium-derived miRNAs in UB development.

Results

Our whole-genome transcriptional profiling showed that the Dicer mutant UB epithelium abnormally retained transcriptional features of the early UB epithelium and failed to express many genes associated with collecting duct differentiation. Furthermore, we identified a temporal expression pattern of early UB genes during UB epithelium development in which gene expression was detected at early developmental stages and became undetectable by embryonic day 14.5. In contrast, expression of early UB genes persisted at later stages in the Dicer mutant UB epithelium and

SUBMITTER: Nagalakshmi VK 

PROVIDER: S-EPMC4344905 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature