Transcriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration.

ABSTRACT:

Rationale

Neonatal mice have the capacity to regenerate their hearts in response to injury, but this potential is lost after the first week of life. The transcriptional changes that underpin mammalian cardiac regeneration have not been fully characterized at the molecular level.

Objective

The objectives of our study were to determine whether myocytes revert the transcriptional phenotype to a less differentiated state during regeneration and to systematically interrogate the transcriptional data to identify and validate potential regulators of this process.

Methods and results

We derived a core transcriptional signature of injury-induced cardiac myocyte (CM) regeneration in mouse by comparing global transcriptional programs in a dynamic model of in vitro and in vivo CM

SUBMITTER: O'Meara CC 

PROVIDER: S-EPMC4344930 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature