Minimizing lipid signal bleed in brain (1) H chemical shift imaging by post-acquisition grid shifting.

ABSTRACT:

Purpose

Low spatial resolution in conventional 1H brain chemical shifting imaging (CSI) studies causes partial volume error (PVE) or signal "bleed" that is especially deleterious to voxels near the scalp. The standard spatial apodization approach adversely affects spatial resolution. Here, a novel automated post-processing strategy of partial volume correction employing grid shifting ("PANGS") is presented, which minimizes residual PVE without compromising spatial resolution.

Methods

PANGS shifts the locations of the reconstruction coordinates in a designated region of image space-the scalp, to match the tissue "centers-of-mass" instead of the geometric centers of each voxel, by iteratively minimizing the PVE from the scalp into outside voxels. PANGS' performance was evaluat

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4344941 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature