IPred - integrating ab initio and evidence based gene predictions to improve prediction accuracy.

ABSTRACT:

Background

Gene prediction is a challenging but crucial part in most genome analysis pipelines. Various methods have evolved that predict genes ab initio on reference sequences or evidence based with the help of additional information, such as RNA-Seq reads or EST libraries. However, none of these strategies is bias-free and one method alone does not necessarily provide a complete set of accurate predictions.

Results

We present IPred (Integrative gene Prediction), a method to integrate ab initio and evidence based gene identifications to complement the advantages of different prediction strategies. IPred builds on the output of gene finders and generates a new combined set of gene identifications, representing the integrated evidence of the single method predictions.

Conc

SUBMITTER: Zickmann F 

PROVIDER: S-EPMC4345001 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature