Dose-response models for selected respiratory infectious agents: Bordetella pertussis, group a Streptococcus, rhinovirus and respiratory syncytial virus.

ABSTRACT:

Background

Dose-response assessment is one step in quantitative microbial risk assessment (QMRA). Four infectious microbes capable of causing respiratory diseases important to public health, and for which dose-response functions have not been available are: Bordetella pertussis (whooping cough), group A Streptococcus (pharyngitis), rhinovirus (common cold) and respiratory syncytial virus (common cold). The objective of this study was to fit dose-response functions for these microbes to published experimental data.

Methods

Experimental infectivity data in human subjects and/or animal models were identified from the peer-reviewed literature. The exponential and beta-Poisson dose-response functions were fitted using the method of maximum likelihood, and models compared by Akaik

SUBMITTER: Jones RM 

PROVIDER: S-EPMC4345006 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature