Obesity, subclinical myocardial injury, and incident heart failure.

ABSTRACT:

Objectives

The study sought to evaluate the association of obesity with a novel biomarker of subclinical myocardial injury, cardiac troponin T measured with a new high-sensitivity assay (hs-cTnT), among adults without clinical cardiovascular disease (CVD).

Background

Laboratory evidence suggests a relationship between obesity and myocardial injury that may play a role in the development of heart failure (HF), but there is limited clinical data regarding this association.

Methods

We evaluated 9,507 participants in the ARIC (Atherosclerosis Risk in Communities) study without baseline CVD (Visit 4, 1996 to 1999). We assessed the cross-sectional association of body mass index (BMI) with high (≥14 ng/l) and measurable (≥3 ng/l) hs-cTnT levels after multivariable regression

SUBMITTER: Ndumele CE 

PROVIDER: S-EPMC4345168 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature