Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases.

ABSTRACT: There is an urgent need to make drug discovery cheaper and faster. This will enable the development of treatments for diseases currently neglected for economic reasons, such as tropical and orphan diseases, and generally increase the supply of new drugs. Here, we report the Robot Scientist 'Eve' designed to make drug discovery more economical. A Robot Scientist is a laboratory automation system that uses artificial intelligence (AI) techniques to discover scientific knowledge through cycles of experimentation. Eve integrates and automates library-screening, hit-confirmation, and lead generation through cycles of quantitative structure activity relationship learning and testing. Using econometric modelling we demonstrate that the use of AI to select compounds economically outperforms standa

SUBMITTER: Williams K 

PROVIDER: S-EPMC4345494 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature