Characterization of expression quantitative trait loci in the human colon.

ABSTRACT:

Background

Many genetic risk loci have been identified for inflammatory bowel disease and colorectal cancer; however, identifying the causal genes for each association signal remains a challenge. Expression quantitative trait loci (eQTL) studies have identified common variants that induce differential gene expression and eQTLs can be cross-referenced with disease association signals for gene prioritization. However, the genetics of gene expression are highly tissue-specific, and further eQTL datasets from primary tissues are needed.

Methods

We have conducted an eQTL discovery study using tissue extracted endoscopically from the terminal ileum and 4 colonic locations of non-inflamed bowel from 65 controls and patients with quiescent inflammatory bowel disease. A genome-wide c

SUBMITTER: Singh T 

PROVIDER: S-EPMC4345969 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature