Linking MRI postprocessing with magnetic source imaging in MRI-negative epilepsy.

ABSTRACT:

Objective

MRI-negative (MRI-) pharmacoresistant focal epilepsy (PFE) patients are most challenging for epilepsy surgical management. This study utilizes a voxel-based MRI postprocessing technique, implemented using a morphometric analysis program (MAP), aiming to facilitate detection of subtle focal cortical dysplasia (FCD) in MRI- patients. Furthermore, the study examines the concordance between MAP-identified regions and localization from magnetic source imaging (MSI).

Methods

Included in this retrospective study were 25 MRI- surgical patients. MAP was performed on T1-weighted MRI, with comparison to a normal database. The pertinence of MAP+ areas was confirmed by MSI, surgical outcome and pathology. Analyses of MAP and MSI were performed blindly from patients' clinical in

SUBMITTER: Wang ZI 

PROVIDER: S-EPMC4346132 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature