Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation.

ABSTRACT:

Purpose of review

Allergic diseases are thought to be driven by aberrant immune responses. Epithelium responds to various environmental factors by releasing key cytokines, such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25. Although there are important differences among these cytokines, there are also similarities which confound a clear understanding of the exact roles of these cytokines. The purpose of this review is to analyze the advances in biology and functions of these cytokines over recent years, elucidate their differences and similarities, and provide new conceptual understanding as to their roles in allergic diseases.

Recent findings

There are distinct differences in the timing, onset, and kinetics of the responses and perhaps in the potency of action of

SUBMITTER: Divekar R 

PROVIDER: S-EPMC4346181 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature