Domestic airborne black carbon levels and 8-isoprostane in exhaled breath condensate among children in New York City.

ABSTRACT:

Background

Exposure to airborne black carbon (BC) has been associated with asthma development, respiratory symptoms and decrements in lung function. However, the mechanism through which BC may lead to respiratory symptoms has not been completely elucidated. Oxidative stress has been suggested as a potential mechanism through which BC might lead to adverse health outcomes. Exhaled breath condensate (EBC) allows for the non-invasive collection of airway lining fluid containing biomarkers of oxidative stress like 8-isoprostane, a stable by-product of lipid peroxidation. Therefore, we sought to characterize the association between domestic airborne BC concentrations and 8-isoprostane in EBC.

Materials and methods

Seven- and eight-year-old children participated in an asthma case-

SUBMITTER: Rosa MJ 

PROVIDER: S-EPMC4346209 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature