Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.

ABSTRACT: The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

SUBMITTER: Deranieh RM 

PROVIDER: S-EPMC4346228 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature