Disruption of frontal-parietal communication by ketamine, propofol, and sevoflurane.

ABSTRACT:

Introduction

Directional connectivity from anterior to posterior brain regions (or "feedback" connectivity) has been shown to be inhibited by propofol and sevoflurane. In this study the authors tested the hypothesis that ketamine would also inhibit cortical feedback connectivity in frontoparietal networks.

Methods

Surgical patients (n = 30) were recruited for induction of anesthesia with intravenous ketamine (2 mg/kg); electroencephalography of the frontal and parietal regions was acquired. The authors used normalized symbolic transfer entropy, a computational method based on information theory, to measure directional connectivity across frontal and parietal regions. Statistical analysis of transfer entropy measures was performed with the permutation test and the time-shift

SUBMITTER: Lee U 

PROVIDER: S-EPMC4346246 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature