Volumetric spectroscopic imaging of glioblastoma multiforme radiation treatment volumes.

ABSTRACT:

Purpose

Magnetic resonance (MR) imaging and computed tomography (CT) are used almost exclusively in radiation therapy planning of glioblastoma multiforme (GBM), despite their well-recognized limitations. MR spectroscopic imaging (MRSI) can identify biochemical patterns associated with normal brain and tumor, predominantly by observation of choline (Cho) and N-acetylaspartate (NAA) distributions. In this study, volumetric 3-dimensional MRSI was used to map these compounds over a wide region of the brain and to evaluate metabolite-defined treatment targets (metabolic tumor volumes [MTV]).

Methods and materials

Volumetric MRSI with effective voxel size of ∼1.0 mL and standard clinical MR images were obtained from 19 GBM patients. Gross tumor volumes and edema were manually outl

SUBMITTER: Parra NA 

PROVIDER: S-EPMC4346247 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature