Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease.

ABSTRACT:

Background

Obesity is frequently complicated by comorbid conditions, yet how excess adipose contributes is poorly understood. Although adipocytes in obese individuals induce systemic inflammation via secreted cytokines, another potential mediator has recently been identified (i.e., adipocyte-derived exosomes). We hypothesized that adipocyte-derived exosomes contain mediators capable of activating end-organ inflammatory and fibrotic signaling pathways.

Methods

We developed techniques to quantify and characterize exosomes shed by adipocytes from seven obese (age: 12-17.5 y, BMI: 33-50 kg/m(2)) and five lean (age: 11-19 y, BMI: 22-25 kg/m(2)) subjects.

Results

Abundant exosomal miRNAs, but no mRNAs, were detected. Comparison of obese vs. lean visceral adipose donors dete

SUBMITTER: Ferrante SC 

PROVIDER: S-EPMC4346410 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature