Chronic hypertension in pregnancy and the risk of congenital malformations: a cohort study.

ABSTRACT:

Objective

Chronic hypertension is a common medical condition in pregnancy. The purpose of the study was to examine the association between maternal chronic hypertension and the risk of congenital malformations in the offspring.

Study design

We defined a cohort of 878,126 completed pregnancies linked to infant medical records using the Medicaid Analytic Extract. The risk of congenital malformations was compared between normotensive controls and those with treated and untreated chronic hypertension. Confounding was addressed using propensity score matching.

Results

After matching, compared with normotensive controls, pregnancies complicated by treated chronic hypertension were at increased risk of congenital malformations (odds ratio [OR], 1.3; 95% confidence interval [

SUBMITTER: Bateman BT 

PROVIDER: S-EPMC4346443 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature