Prognostic significance and molecular features of signet-ring cell and mucinous components in colorectal carcinoma.

ABSTRACT:

Background

Colorectal carcinoma (CRC) represents a group of histopathologically and molecularly heterogeneous diseases, which may contain signet-ring cell component and/or mucinous component to a varying extent under pathology assessment. However, little is known about the prognostic significance of those components, independent of various tumor molecular features.

Methods

Utilizing a molecular pathological epidemiology database of 1,336 rectal and colon cancers in the Nurses' Health Study and the Health Professionals Follow-up Study, we examined patient survival according to the proportion of signet-ring cell and mucinous components in CRCs. Cox proportional hazards models were used to compute hazard ratio (HR) for mortality, adjusting for potential confounders including st

SUBMITTER: Inamura K 

PROVIDER: S-EPMC4346446 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature