Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation.

ABSTRACT:

Background

New-onset diabetes after transplantation (NODAT) is a serious complication in transplant recipients. Transcription factor-7-like 2 (TCF7L2) is a Wnt signaling-associated transcription factor that plays an important role in β-cell proliferation and insulin secretion. The association between TCF7L2 SNP rs7903146 and NODAT was documented in renal transplant patients.

Objective

To determine the association between TCF7L2 rs7903146 variants and the risk of NODAT after liver transplantation.

Methods

This study was conducted on 140 liver transplant recipients who had received tacrolimus-based immunosuppressive drugs. The patients were divided into NODAT (n=70) and non-NODAT (n=70) groups and were genotyped using PCR-RFLP. In addition, 100 normal subjects were cons

SUBMITTER: Musavi Z 

PROVIDER: S-EPMC4346459 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature