TWEAK-Fn14 pathway activation after exercise in human skeletal muscle: insights from two exercise modes and a time course investigation.

ABSTRACT: The cell surface receptor Fn14/TWEAKR was recently reported by our laboratory to be a prominent marker in the resistance exercise (RE) induced Transcriptome. The purpose of the present study was to extend our Transcriptome findings and investigate the gene and protein expression time course of markers in the TWEAK-Fn14 pathway following RE or run exercise (RUN). Vastus lateralis muscle biopsies were obtained from 6 RE subjects [25 ± 4 yr, 1-repetition maximum (RM): 99 ± 27 kg] pre- and 0, 1, 2, 4, 8, 12, and 24 h post RE (3 × 10 at 70% 1-RM). Lateral gastrocnemius biopsies were obtained from 6 RUN subjects [25 ± 4 yr, maximum oxygen uptake (V̇O2max): 63 ± 8 ml·kg(-1)·min(-1)] pre- and 0, 1, 2, 4, 8, 12, and 24 h after a 30-min RUN (75% V̇O2max). After RE, Fn14 gene and protein expression w

SUBMITTER: Raue U 

PROVIDER: S-EPMC4346742 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature