Development of a biological scaffold engineered using the extracellular matrix secreted by skeletal muscle cells.

ABSTRACT: The performance of implantable biomaterials derived from decellularized tissue, including encouraging results with skeletal muscle, suggests that the extracellular matrix (ECM) derived from native tissue has promising regenerative potential. Yet, the supply of biomaterials derived from donated tissue will always be limited, which is why the in-vitro fabrication of ECM biomaterials that mimic the properties of tissue is an attractive alternative. Towards this end, our group has utilized a novel method to collect the ECM that skeletal muscle myoblasts secrete and form it into implantable scaffolds. The cell derived ECM contained several matrix constituents, including collagen and fibronectin that were also identified within skeletal muscle samples. The ECM was organized into a porous network

SUBMITTER: Hurd SA 

PROVIDER: S-EPMC4346781 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature