Molecular classification of outcomes from dengue virus -3 infections.

ABSTRACT:

Objectives

Dengue virus (DENV) infection is a significant risk to over a third of the human population that causes a wide spectrum of illness, ranging from sub-clinical disease to intermediate syndrome of vascular complications called dengue fever complicated (DFC) and severe, dengue hemorrhagic fever (DHF). Methods for discriminating outcomes will impact clinical trials and understanding disease pathophysiology.

Study design

We integrated a proteomics discovery pipeline with a heuristics approach to develop a molecular classifier to identify an intermediate phenotype of DENV-3 infectious outcome.

Results

121 differentially expressed proteins were identified in plasma from DHF vs dengue fever (DF), and informative candidates were selected using nonparametric statistic

SUBMITTER: Brasier AR 

PROVIDER: S-EPMC4346782 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature