Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb Folium eriobotryae.

ABSTRACT: Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are ide

SUBMITTER: Zhang J 

PROVIDER: S-EPMC4346873 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature