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A time to kill: targeting apoptosis in cancer.

ABSTRACT: The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy.

SUBMITTER: Koff JL

PROVIDER: S-EPMC4346874 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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A time to kill: targeting apoptosis in cancer.

Koff Jean L JL Ramachandiran Sampath S Bernal-Mizrachi Leon L

International journal of molecular sciences 20150128 2

The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitiz ...[more]

PMID: 25636036

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